Report of The Fourth A3 Roundtable Meeting on Asia Chemical Probe Research Hub

Kengo Hayashi
Graduate School of Sciences, Tohoku University, Japan

First, I would like to thank the organizers of JSPS A3 Foresight Program for giving me such a wonderful opportunity to join the 4th A3 Roundtable Meeting on Chemical Probe Research Hub held in Sendai, Japan in 2019. It was the first experience to talk our research project in international symposium and it became a precious experience.
The title of my presentation (10 min) was “Tuning the target selectivity of Coronatine using the stereochemical library strategy” in 2nd day of the meeting. I talked about development of the target selective analog of multi-functional natural product, coronatine. Regulation of the target selectivity of natural product is one of the significant issues of chemical biology research. Our approach to achieve the purpose is using the stereoisomer of the natural product because stereoisomers of the natural product have same size and a little different three-dimensional structure. We constructed stereochemical library of coronatine and assessed the target selectivity of the stereoisomers. From in vitro analysis, we developed the target selective analog from the stereochemical library of coronatine. During or after the session, I got some questions and comments about my research from professors and young scientists. Comments and suggestions from everyone encouraged me much more than before and deepened my understanding of our research.
In addition, some organizers said that making friends is also the purpose of this meeting. It was good chance for me to communicate with the students from other country. At the dinner time, I had a lot of talk about research, their laboratories, usual life in their country and their future with young scientists in Korea and China. I am looking forward to meeting them again. Finally, I would like to appreciate all organizers and all members in this meeting again.