Report of The Fourth A3 Roundtable Meeting on Asia Chemical Probe Research Hub

Hui-Yun Hwang, PhD candidate
Chemical Genomics Global Research Lab.,
Yonsei University, Korea

 First of all, I am deeply grateful to the A3 Foresight Program and all participants for giving me a great opportunity to participate “The Fourth A3 Roundtable Meeting on Asia Chemical Probe Research Hub” in Sendai, Japan, Nov. 18-21, 2019. It was my first time to participate this A3 meeting with oral presentation. The title of my oral presentation was “Quantitative proteomics analysis using label-free method deconvolutes a target protein of autophagy-regulating small molecule”. We discovered autophagy-regulating small molecule, APZ, which exhibits a promising activity for treating cancer. By using the label-free drug affinity responsive target stability (DARTS) method with a liquid chromatography/tandem mass spectrometry, we identified the biologically relevant target protein of APZ. Having many questions and comments from audiences, I felt that they were gathered in this meeting with the tremendous passion for chemical biology.

 It was my great honor and pleasure to meet many famous professors and heard their excellent research including target identification, chemical probes discovery, synthetic application, development and application of PPI, diseases targeting strategies, and so on. I was so amazed by young scientists, in that they have the great and unique results with recent attraction. From them, I could learn much knowledge with great inspiration and expansion to my research. Accordingly, I want to apply the recent experiments of target identification and validation to clear the real binding motif between my bioactive small molecules and their target proteins. Through the meeting in Sendai, I gained the precious experiences to engage as a young scientist with passion for chemistry and biology interface. Finally, I am deeply grateful to the organizers and all participants again.